Apolipoprotein E ϵ4 Allele and Familial Aggregation of Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis
Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment...
متن کاملApolipoprotein E and Alzheimer disease.
Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been identified in the binding of apoE to the microtubule-associated protein tau, w...
متن کاملApolipoprotein E ε4 allele and malondialdehyde level are independent risk factors for Alzheimer’s disease
BACKGROUND The ε4 allele of Apolipoprotein E is involved in lipid metabolism. Oxidative stress produces an increase in lipid peroxidation that has been implicated in the pathogenic cascade in Alzheimer's disease. This study estimated the effect of the ε4 allele, malondialdehyde and lipid levels on the risk for Alzheimer's disease. METHODS A total of 41 control subjects and 73 patients with Al...
متن کاملIncidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status.
CONTEXT Few studies compare Alzheimer disease (AD) incidence among black and white subjects. OBJECTIVE To estimate incidence and the effect of the apolipoprotein E (APOE) epsilon4 allele in these races. DESIGN Population-based study of disease incidence using a random, stratified sample. SETTING A geographically defined community of 3 adjacent neighborhoods in Chicago, Ill. PARTICIPANTS...
متن کاملModification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep.
IMPORTANCE The apolipoprotein E (APOE [GenBank, 348; OMIM, 107741]) ε4 allele is a common and well-established genetic risk factor for Alzheimer disease (AD). Sleep consolidation is also associated with AD risk, and previous work suggests that APOE genotype and sleep may interact to influence cognitive function. OBJECTIVE To determine whether better sleep consolidation attenuates the relation...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 1998
ISSN: 0003-9942
DOI: 10.1001/archneur.55.6.810